Synthesis and biological activity of benzothiazolo-and benzoxazolo [3, 2-a] quinolinium salts

…, H Jackson, VA Vargas, A Baez, JI Colon…

文献索引：Cox; Jackson; Vargas; Baez; Colon; Gonzalez; de Leon Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1378 - 1381

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被引用次数: 56

摘要

2 and nitidine (lb) 3 represent a class of compounds isolated from the Rutaceae family that show potent antitumor activity against L1210 and P-388 murine leukemias. Coralyne (2),* a berbenium alkaloid structurally related to the benzo [c] phenantridines, exhibits antitumor activity against both tumor screens. Studies on the mechanism of action of fagaronine and nitidine indicate that both alkaloids inhibit DNA synthesis probably by interacting with AT ...