Thirty two guanylhydrazones of aromatic ketones were synthesized and teated in the primary aiitiinalarial scieen in mice infected with Plasmodzum berghei. Sine compounds showed significant activity and seven of these gave a high percentage of ciireb. The biological results and structure-activity correlation are discussed as well as drug design arid the syiithetic problems involved. Activity of some of these compounds on L1210 leukemia ...
