Journal of Heterocyclic Chemistry

Bromine??induced cyclization of 1??acyl??3??(3??thienyl)??2??thioureas to 2??acylaminothieno [3, 2??d] thiazoles

L Grehn

文献索引：Grehn,L. Journal of Heterocyclic Chemistry, 1978 , vol. 15, p. 81 - 87

被引用次数: 13

摘要

Abstract Three different 1-acyl-3-(3-thienyl)-2-thioureas were cyclized to 2-acylaminothieno [3, 2-d] thiazoles with bromine in acetic acid whereas the corresponding 2-thienylthiourea derivatives were brominated under the same reaction conditions. The parent thieno [3, 2-d] thiazole was prepared by acid hydrolysis and deamination of 2-benzoylaminothieno [3, 2-d] thiazole. This new heterocyclic compound was nitrated and brominated in the 5-position.