Bioorganic & medicinal chemistry letters

Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora

C Yenjai, S Wanich

文献索引：Yenjai, Chavi; Wanich, Suchana Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2821 - 2823

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被引用次数: 27

摘要

Flavones 1–4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a–4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, ...