Synthesis and anti-inflammatory activity of 1-acetyl-5-substitute daryl-3-(β-aminonaphthyl)-2-pyrazolines and β-(substitute daminoethyl) amidonaphthalenes

E Bansal, VK Srivastava, A Kumar

文献索引：Bansal, Ekta; Srivastava; Kumar, Ashok European Journal of Medicinal Chemistry, 2001 , vol. 36, # 1 p. 81 - 92

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被引用次数: 141

摘要

The title compounds were prepared by reaction of β-acetylamino-naphthalene with different aromatic aldehydes followed by cyclisation with hydrazine hydrate and with different primary or secondary amines (Mannich's reaction), respectively. The structures of new compounds were confirmed by 1H-NMR and IR spectral data. Anti-inflammatory and ulcerogenic activities in vivo were evaluated and compared with the standard drugs, phenylbutazone ...