Il Farmaco

Synthesis, physicochemical and anticonvulsant properties of N-benzyl and N-aminophenyl derivatives of 2-azaspiro [4.4] nonane and [4.5] decane-1, 3-dione. Part I

…, A Zagorska, P Zajdel, J Karolak-Wojciechowska

文献索引：Obniska, Jolanta; Dzierzawska-Majewska, Agnieszka; Zagorska, Agnieszka; Zajdel, Pawel; Karolak-Wojciechowska, Janina Farmaco, 2005 , vol. 60, # 6-7 p. 529 - 539

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被引用次数: 15

摘要

To continue our systematic SAR studies, two series of N-benzyl-(X= CH2) and N- aminophenyl-(X= NH) derivatives of 2-azaspiro [4.4] nonane (1a–1j) and 2-azaspiro [4.5] decane-1, 3-dione (2a–2j) were synthesized, and evaluated in maximum electroshock seizure (MES), subcutaneous pentylenetetrazole (sc. MET) and rotorod (TOX) tests for their anticonvulsant activity. Among those derivatives, the most potent N-aminophenyl-2- ...