Journal of medicinal chemistry

Synthesis and biological evaluation of sparsomycin analogs

SS Duke, MR Boots

文献索引：Duke, Scherer S.; Boots, Marvin R. Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1556 - 1561

全文：HTML全文

被引用次数: 10

摘要

Three series of sparsomycin analogues were prepared and examined for their ability to inhibit DNA or protein synthesis in bone marrow, P388 lymphocytic leukemia, and P815 mastocytoma cells. The compounds of series I and 11, distinguished by the inclusion or exclusion of a hydroxymethyl functional group, were designed to elucidate the effect on activity of replacing the oxodithioacetal side chain of sparsomycin with 4-substituted ...