Journal of the American Chemical Society

The Friedel—Crafts Reaction with o-Nitrophenol and Acyl Halides1

FC Brown

文献索引：Brown Journal of the American Chemical Society, 1946 , vol. 68, p. 872

被引用次数: 15

摘要

According to the present conception of the Friedel-Crafts reaction, a positive alkyl or acyl ion attacks the aromatic hydrocarbon at that position where the center of electron density is greatest. When the electron density of the hydrocarbon is decreased by the presence of meta-directing substituents, reaction takes place less readily or fails completely. Nitrobenzene is so inert that it may be used as a solvent for other more reactive aromatic ...

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[Chancellor, Daniel R.; Davies, Kay E.; De Moor, Olivier; Dorgan, Colin R.; Johnson, Peter D.; Lambert, Adam G.; Lawrence, Daniel; Lecci, Cristina; Maillol, Carole; Middleton, Penny J.; Nugent, Gary; Poignant, Severine D.; Potter, Allyson C.; Price, Paul D.; Pye, Richard J.; Storer, Richard; Tinsley, Jonathon M.; Van Well, Renate; Vickers, Richard; Vile, Julia; Wilkes, Fraser J.; Wilson, Francis X.; Wren, Stephen P.; Wynne, Graham M. Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3241 - 3250]