Electrochemistry of potentially bioreductive alkylating quinones. Part 4. Qualitative and quantitative structure??activity relationships of aziridinylquinones

RJ Driebergen, EE Moret, LHM Janssen…

文献索引：Driebergen, R. J.; Moret, E. E.; Janssen, L. H. M.; Beijnen, J. H.; Holthuis, J. J. M.; et al. Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 2 p. 174 - 185

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被引用次数: 7

摘要

Abstract The concept of bioreductive alkylation as a mechanism of action of aziridinylquinoid anticancer agents has been investigated. The influence of quinone substituents on quinone reduction, on protonation of the aziridines prior to and following quinone reduction and on partitioning properties of the compound was examined. Parameters obtained from a combined electrochemical, chemical-stability and lipophilicity study describing these ...