Synthesis and primary cytotoxicity evaluation of new 5-benzylidene-2, 4-thiazolidinedione derivatives

V Patil, K Tilekar, S Mehendale-Munj, R Mohan…

文献索引：Patil, Vijay; Tilekar, Kalpana; Mehendale-Munj, Sonali; Mohan, Rhea; Ramaa European Journal of Medicinal Chemistry, 2010 , vol. 45, # 10 p. 4539 - 4544

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被引用次数: 57

摘要

In the present work, ten novel derivatives (3a–3j) of 5-benzylidene-2, 4-thiazolidinediones were synthesized and their structures were determined by analytical and spectral (FTIR, 1H NMR, 13C NMR) methods. The newly synthesized compounds were evaluated for their antiproliferative activity at Tata Memorial's Advanced Center for Treatment, Research and Education in Cancer (ACTREC), India, in a panel of 7 cancer cell lines using four ...