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Journal of medicinal chemistry

Synthesis of 1, 4-Naphthohydroquinone-2-carboxanilide and 1, 4-Naphthoquinone-2-carboxanilide1

K Swiatek, SB Binkley

文献索引:Swiatek,K.; Binkley,S.B. Journal of Medicinal Chemistry, 1964 , vol. 7, p. 393

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被引用次数: 0

摘要

1, 4-Dihydroxy-Z-naphthoic A~ id.~-JVlien this c~ Jlr~ p~ Jlilld I\ as inade according to the procedure of Homeyer and\?'allingford, 7: I red oil was often obtained in the preparation of the intermediate compound, diethyl 1, 4-dihg-droxy-2, 3-naphthalate. This difficulty\ vas overcome when NaH was substituted for NaOC2Hj in the condensation of ethyl phthalate and ethyl succinate, and by running the reaction in anhydrous ether. The melting point of ...