Structure–activity relationship study of arylsulfonylimidazolidinones as anticancer agents

VK Sharma, KC Lee, E Venkateswararao, C Joo…

文献索引：Sharma, Vinay K.; Lee, Ki-Cheul; Venkateswararao, Eeda; Joo, Cheonik; Kim, Min-Seok; Sharma, Niti; Jung, Sang-Hun Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6829 - 6832

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被引用次数: 7

摘要

In an effort to find novel N-arylsulfonylimidazolidinones as highly potent anticancer agent, the structure–activity relationship of ethyl 2-methyl-4-(2-oxo-4-phenylimidazolidin-1- ylsulfonyl) phenylcarbamate was explored through synthesis and evaluation of in vitro cytotoxicity of its analogs against HCT116, A549 and NCL-H460 cancer cell lines. Among the synthesized derivatives, the carbamate analogs (4a–f and 4k–p) exhibited superior ...