Tetrahedron letters

Synthesis of 5-methylfuro [3, 2-c] quinolin-4 (5H)-one via palladium-catalysed cyclisation of N-(2-iodophenyl)-N-methyl-3-furamide

KF Lindahl, A Carroll, RJ Quinn, JA Ripper

文献索引：Lindahl, Karl-Fredrik; Carroll, Anthony; Quinn, Ronald J.; Ripper, Justin A. Tetrahedron Letters, 2006 , vol. 47, # 42 p. 7493 - 7495

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被引用次数: 14

摘要

A new synthesis of the furo [3, 2-c] quinolin-4 (5H)-one heterocycle has been developed using a palladium-catalysed cyclisation of N-(2-iodophenyl)-N-methyl-3-furamide. By varying the catalyst, base and solvent, the yield of the cyclisation was optimised. It was found that the use of palladium oxide with potassium acetate in N, N-dimethylacetamide (DMA) with a small amount of tetrabutylammonium chloride gave the highest yield of 5-methylfuro ...