Tetrahedron letters

Solid-phase synthesis of substituted 3-amino-3′-carboxy-tetrahydrocarbazoles

M Koppitz, G Reinhardt, A van Lingen

文献索引：Koppitz, Marcus; Reinhardt, Gabriele; Van Lingen, Anneke Tetrahedron Letters, 2005 , vol. 46, # 6 p. 911 - 914

全文：HTML全文

被引用次数: 15

摘要

Two related solid-phase synthesis routes have been developed allowing the synthesis of 3- amino-3′-carboxy substituted tetrahydrocarbazole derivatives. Diversity can be introduced at the amino and carboxy functionalities and at the nitrogen and the aromatic ring of the tetrahydrocarbazole moiety. Both routes rely on Fmoc-protected 1-amino-4- oxocyclohexanone carboxylic acid as central core element. Derivatization of the carboxy ...