Synthesis of 2, 5-thiazole butanoic acids as potent and selective α v β 3 integrin receptor antagonists with improved oral pharmacokinetic properties

JA Wendt, H Wu, HG Stenmark, ML Boys…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 4 p. 845 - 849

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被引用次数: 7

摘要

... Bioorganic & Medicinal Chemistry Letters. ... b Department of Medicinal Chemistry, Pfizer Global Research and Development, 4901 Searle Parkway, Skokie, IL 60077, USA; c Departments of Discovery ... The initial chemical scaffold was very similar to the RGD sequence in vitronectin ...