Tetrahedron letters

Mild electrophilic halogenation of chloropyridines using CCl 4 or C 2 Cl 6 under basic phase transfer conditions

…, M Baidossi, N Qafisheh, E Chachashvili, Y Sasson

文献索引：Joshi, Ashutosh V.; Baidossi, Mubeen; Qafisheh, Nida; Chachashvili, Elsa; Sasson, Yoel Tetrahedron Letters, 2004 , vol. 45, # 26 p. 5061 - 5063

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被引用次数: 5

摘要

Effective chlorination of 2, 3, 5, 6-tetrachloropyridine to pentachloropyridine was realized under mild phase transfer conditions with carbon tetrachloride and 50% NaOH or solid K3PO4. Mechanistic study of this reaction indicated the possibility of an aromatic carbanionic intermediate. Hexachloroethane was established as a more selective electrophilic chlorination agent.