Tetrahedron letters

A novel reagent for labelling macromolecules with intensely luminescent lanthanide complexes

JB Lamture, TG Wensel

文献索引：Lamture, Jagannath B.; Wensel, Theodore G. Tetrahedron Letters, 1993 , vol. 34, # 26 p. 4141 - 4144

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被引用次数: 21

摘要

Abstract A novel bifunctional chelator, 4-iodoacetamidodipicolinicacid, has been synthesized in three steps starting with chelidamic acid, and used to prepare protein conjugates that form stable and intensely luminescent complexes with Tb (III) and Eu (III). The excited state lifetime of Tb (III) complexes with this reagent was 1.25 ms, permitting its use for ultrasensitive time-resolved luminescence assays.