A practical synthesis of mitomycin A and its analogs

…, D Benigni, RA Partyka, TW Doyle

文献索引：Vyas; Benigni; Partyka; Doyle Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4307 - 4309

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被引用次数: 34

摘要

Mitomycin C (1), 1, 2 an antineoplastic antibiotic isolated from fermentation broth of Streptomyces caespetosius, is currently used clinically in combination cancer chemotherapy against a wide variety solid tum01-s.~ Analogue research targeted toward more efficacious and less myelosuppressive derivatives has proceeded at a steady pace. A useful semisynthetic approach has centered on the synthesis of 7-substituted mitosanes, namely, ...