A novel approach for the synthesis of 5-substituted-1H-tetrazoles

B Akhlaghinia, S Rezazadeh

文献索引：Akhlaghinia, Batool; Rezazadeh, Soodabeh Journal of the Brazilian Chemical Society, 2012 , vol. 23, # 12 p. 2197 - 2203

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被引用次数: 19

摘要

ABSTRACT A series of 5-substituted-1H-tetrazoles (RCN 4 H) have been synthesized by cycloaddition reaction of different aryl and alkyl nitriles with sodium azide in DMSO using CuSO 4• 5H 2 O as catalyst. A wide variety of aryl nitriles underwent [3+ 2] cycloaddition to afford tetrazoles under mild reaction conditions in good to excellent yields. The catalyst used is readily available and environmentally friendly. Short reaction times, good to excellent ...