ABSTRACT A series of 5-substituted-1H-tetrazoles (RCN 4 H) have been synthesized by cycloaddition reaction of different aryl and alkyl nitriles with sodium azide in DMSO using CuSO 4• 5H 2 O as catalyst. A wide variety of aryl nitriles underwent [3+ 2] cycloaddition to afford tetrazoles under mild reaction conditions in good to excellent yields. The catalyst used is readily available and environmentally friendly. Short reaction times, good to excellent ...
