Journal of organometallic chemistry

Rhodium (I)-or ruthenium (II)-catalyzed direct coupling of vinyl ketones with aldehydes and the subsequent reduction to give aldol derivatives anti-selectively

S Sato, I Matsuda, M Shibata

文献索引：Sato, Susumu; Matsuda, Isamu; Shibata, Masahiro Journal of Organometallic Chemistry, 1989 , vol. 377, p. 347 - 356

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被引用次数: 3

摘要

Abstract A vinyl ketone reacts with an aldehyde to give an α-methylene-β-hydroxyalkanone with the concomitant formation of the vinyl ketone dimer in the presence of catalytic amount of RhH (PPh 3) 4 or RuH 2 (PPh 3) 4 under almost neutral conditions. The selectivity of the cross-coupling product is remarkably improved in the presence of an extra mole of aldehyde. This type of cross-coupling is explained by the intermediacy of the transition ...