Synthesis and Evaluation of a Novel Series of Pyrrolizine Derivatives as Dual Cyclooxygenase??1 and 5??Lipoxygenase Inhibitors

…, T Kammermeier, G Dannhardt, W Kiefer

文献索引：Laufer, Stefan; Striegel, Hans-Guenter; Neher, Karola; Zechmeister, Pia; Donat, Cornelia; Stolingwa, Katrin; Baur, Sibylle; Tries, Susanne; Kammermeier, Thomas; Dannhardt, Gerd; Kiefer, Werner Archiv der Pharmazie, 1997 , vol. 330, # 9-10 p. 307 - 312

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被引用次数: 26

摘要

Abstract The aim of our study was to investigate structure activity relationship following the replacement of the 6-phenyl substituent at the 6, 7-diaryl-2, 3-dihydropyrrolizine template by various heteroaromatic residues. In this context we developed a new, efficient, and highly sensitive test method for the screening of dual cyclooxygenase-1 (COX-1) and 5- lipoxygenase (5-LOX) inhibitors. We used human platelets as a source of COX-1 and ...