Tetrahedron

Regioselective addition of organomagnesium reagents to N-silyl activated nicotinic acid esters—a convenient method for the synthesis of 4, 4-disubstituted 1, 4- …

CA Sperger, KT Wanner

文献索引：Braeckow, Jan; Wanner, Klaus T. Tetrahedron, 2006 , vol. 62, # 10 p. 2395 - 2404

全文：HTML全文

被引用次数: 11

摘要

The addition of RMgX or R2Mg to nicotinic acid esters, activated with triisopropylsilyl triflate, was investigated. The regioselectivity of this reaction, where 4-unsubstituted and 4- substituted pyridine derivatives were employed as starting materials, was examined.