An efficient synthesis of 1-cyanoacetyl-5-halomethyl-4, 5-dihydro-1H-pyrazoles in ionic liquid

…, CP Frizzo, K Longhi, N Zanatta, HG Bonacorso…

文献索引：Moreira, Dayse N.; Frizzo, Clarissa P.; Longhi, Kelvis; Zanatta, Nilo; Bonacorso, Helio G.; Martins, Marcos A. P. Monatshefte fur Chemie, 2008 , vol. 139, # 9 p. 1049 - 1054

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被引用次数: 25

摘要

Abstract The synthesis of eleven 1-cyanoacetyl-5-hydroxy-5-halomethyl-4, 5-dihydro-1 H- pyrazoles from the reaction of 4-alkoxy-3-alken-2-ones f (R 3 C (O) C (R 2)= C (R 1) OR, where R 3= CF 3, CCl 3, CHCl 2, CO 2 Et; R 2/R 1= H/H, H/Me, H/Et,-(CH 2) 4-, Me/H, H/Pr, and R= Me, Et) with cyanoacetohydrazide is reported. The reaction was carried out in the ionic liquid ([bmim][BF 4]) and molecular solvents. The results showed that when the ionic ...