Biomacromolecules

Engineered polymer nanoparticles containing hydrophobic dipeptide for inhibition of amyloid-β fibrillation

H Skaat, R Chen, I Grinberg, S Margel

文献索引：Skaat, Hadas; Chen, Ravit; Grinberg, Igor; Margel, Shlomo Biomacromolecules, 2012 , vol. 13, # 9 p. 2662 - 2670

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被引用次数: 29

摘要

Protein aggregation into amyloid fibrils is implicated in the pathogenesis of many neurodegenerative diseases. Engineered nanoparticles have emerged as a potential approach to alter the kinetics of protein fibrillation process. Yet, there are only a few reports describing the use of nanoparticles for inhibition of amyloid-β 40 (Aβ40) peptide aggregation, involved in Alzheimer's disease (AD). In the present study, we designed new ...