Deaza analogues of adenosine as inhibitors of blood platelet aggregation

…, G Cristalli, P Franchetti, M Grifantini…

文献索引：Antonini; Cristalli; Franchetti; Grifantini; Martelli; Petrelli Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 3 p. 366 - 369

全文：HTML全文

被引用次数: 38

摘要

Abstract A number of deaza analogues of adenosine were prepared and tested as inhibitors of platelet aggregation induced by ADP and collagen to investigate the structure-activity relationships in this class of nucleoside analogues. The results showed that the presence of a 6-amino group and nitrogen atoms at positions 3 and 7 of the purine moiety are required for inhibitory activity.