Rearrangements of Substituted 3-Aza-1, 2, 5-hexatrienes. 3. The Scope and Versatility of an Extremely Mild 3-Aza-Cope Reaction

…, AB Hoem, CS McDonough

文献索引：Walters, Michael A.; Hoem, Andrew B.; McDonough, Colleen S. Journal of Organic Chemistry, 1996 , vol. 61, # 1 p. 55 - 62

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被引用次数: 17

摘要

An investigation of the [3, 3]-sigmatropic reaction of substituted 3-aza-1, 2, 5-hexatrienes to give 4-pentenenitriles is presented. This reaction has been found to occur under a wide variety of reactions conditions (10 are reported) starting from readily available N-allylamides. In contrast to other 3-aza-Cope reactions, this process occurs at room temperature, under essentially neutral conditions, allowing for the facile preparation of substituted nitrile ...