The synthesis, structure-activity, and structure-side effect relationships of a series of 8-alkoxy-and 5-amino-8-alkoxyquinolone antibacterial agents
…, RD Gogliotti, JM Domagala, SJ Gracheck…
文献索引：Sanchez, Joseph P.; Gogliotti, Rocco D.; Domagala, John M.; Gracheck, Stephen J.; Huband, Michael D.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4478 - 4487
A series of l-cyclopropyl-6-fluoro-8-alkoxy (8-methoxy and 8-ethoxy~-quionoline-3- carboxylic acids and l-cyclopropyl-5-amino-6-fluoro-8-alkoxyquinoline-3-carboxylic acids has been prepared and evaluated for antibacterial activity. In addition, they were also compared to quinolones with classic substitution at Cx (H, F, C1) and the naphthyridine nucleus in a phototoxicity and mammalian cell cytotoxicity assay. The series of 8- ...
