Synthesis of N, N′-disubstituted 3-aminobenzo [c] and [d] azepin-2-ones as potent and specific farnesyl transferase inhibitors

…, D Shanks, N Guilbaud, A Pierre, E Raimbaud…

文献索引：Le Diguarher, Thierry; Ortuno, Jean-Claude; Shanks, David; Guilbaud, Nicolas; Pierre, Alain; Raimbaud, Eric; Fauchere, Jean-Luc; Hickman, John A.; Tucker, Gordon C.; Casara, Patrick J. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 767 - 771

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被引用次数: 24

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A structure–activity study was performed by synthesis on N,N′-disubstitution of 3-aminobenzo[c] and [d]azepin-2-one 2 and 3 to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities. ... A structure–activity study was ...