DNA interstrand cross-linking reactions of pyrrole-derived, bifunctional electrophiles: evidence for a common target site in DNA

J Woo, ST Sigurdsson, PB Hopkins

文献索引：Woo, Jinsuk; Sigurdsson, Snorri Th.; Hopkins, Paul B. Journal of the American Chemical Society, 1993 , vol. 115, # 9 p. 3407 - 3415

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被引用次数: 110

摘要

Abstract: The site of DNA interstrand cross-linking identified by a family of pyrrole-derived bifunctional electrophiles was studied in vitro in synthetic DNA duplexes. This family includes reductively activated mitomycin C (l), oxidatively activated pyrrolizidine alkaloids (eg 2), the simple pyrroles 2, 3-and 3, 4-bis-(acetoxymethyl)-1-methylpyrrole (3 and 4), and the antitumor substance 2, 3-dihydro-5-(3', 4'-dichlorophenyl)-6, 7-bis (hydroxymethyl)-1H- ...