SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK 1 antagonist

…, K Hauser, W Schilling, A Vassout, SJ Veenstra

文献索引：Ofner, Silvio; Hauser, Kathleen; Schilling, Walter; Vassout, Annick; Veenstra, Siem J. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 14 p. 1623 - 1628

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被引用次数: 35

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Novel 2-benzyl-4-aminopiperidines have been shown to be potent and selective antagonists at the NK 1 receptor. Some compounds of this series, eg CGP 49823 (2), show CNS activity after oral administration. ... Novel 2-benzyl-4-aminopiperidines have been shown to be potent ...