Quinazolinediones are important heterocycles 1 and have been shown to possess pharmacologically interesting properties, displaying, for example, anti-hypertensive, 2 antidiabetic, 3 and immunosuppressive activities. 4 Among these, synthetic pelanserine (TR2515)(1) 5 is a well established potent anti-hypertensive agent, having activity comparable to the clinically used ketanserin 6 (Figure 1). Goshuyuamide II (2) is isolated ...
