Synthesis and antitrichinellosis activity of some 2-substituted-[1, 3] thiazolo [3, 2-a] benzimidazol-3 (2H)-ones

AT Mavrova, KK Anichina, DI Vuchev, JA Tsenov…

文献索引：Mavrova, Anelia Ts.; Anichina, Kamelya K.; Vuchev, Dimitar I.; Tsenov, Jordan A.; Kondeva, Magdalena S.; Micheva, Mitka K. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 19 p. 5550 - 5559

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被引用次数: 51

摘要

Some new thiazolo [3, 2-a] benzimidazolone derivatives were synthesized using two methods. The structures of the synthesized compounds were proved by means of IR, 1H NMR and mass spectral data. Ab initio computations were performed in order to determine the electronic structure and geometry of the investigated molecules and to compare it to the geometry of albendazole. Biologically, experiments in vitro and in vivo were accomplished ...