European journal of medicinal chemistry

Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity

S Zakir, M Patel, M Farooqui

文献索引：Ali, Nasir Ali Shafakat; Zakir, Shaikh; Patel, Muqtadir; Farooqui, Mazahar European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 39 - 43

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被引用次数: 26

摘要

We are reporting herein for the first time the synthesis of α-aminophosphonates containing Indazole moiety in two steps. In the first step, imines of substituted N-benzylidene-1-methyl- 1H-indazole-3-carbohydrazide are synthesized and in the next step it has converted to α- aminophosphonates using chlorotrimethylsilane (TMSCl) and triethyl phosphite. Some of the synthesized derivatives are evaluated for antibacterial activity against different bacterial ...