Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl) quinoline-sulfonamide as hybrid antiprotozoal agents

A Salahuddin, A Inam, RL van Zyl, DC Heslop…

文献索引：Salahuddin, Attar; Inam, Afreen; Van Zyl, Robyn L.; Heslop, Donovan C.; Chen, Chien-Teng; Avecilla, Fernando; Agarwal, Subhash M.; Azam, Amir Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 3080 - 3089

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被引用次数: 22

摘要

A new series of 4-aminochloroquinoline based sulfonamides were synthesized and evaluated for antiamoebic and antimalarial activities. Out of the eleven compounds evaluated (F1–F11), two of them (F3 and F10) showed good activity against Entamoeba histolytica (IC50< 5μM). Three of the compounds (F5, F7 and F8) also displayed antimalarial activity against the chloroquine-resistant (FCR-3) strain of Plasmodium falciparum with ...