Analogues of oxytocin and vasopressin with and N α-methylamino acid residue in position 8

J Hlaváček, K Poduška, K Jošt, I Frič…

文献索引：Hlavacek; Poduska; Jost; et al. Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 4 p. 1233 - 1247

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被引用次数: 7

摘要

The syntheses of two analogues of neurohypophysial hormones are described, in which the residue in sequence position 8 was replaced by an N"-methylamino acid:[8-N- methylleucineJoxytocin. and [8-N"-methylarginineJdeamino-vasopressin. Alkylation of the ex-nitrogen atom at this position resulted in a moderate to marked reduction in some biological actions of the parent substances in terms of potency (particularly with anti ...