The Journal of Organic Chemistry

Displacements at the nitrogen of lithioalkoxylamides by organometallic reagents

P Beak, GW Selling

文献索引：Beak, Peter; Selling, Gordon W. Journal of Organic Chemistry, 1989 , vol. 54, # 23 p. 5574 - 5580

全文：HTML全文

被引用次数: 47

摘要

Cyclizations. This amination strategy can be used to form nitrogen-containing rings. The sequence which begins with the preparation of the appropriate (o-bromo-pheny1) alkanylmethoxylamine by straightforward methodology is illustrated by the synthesis of N- acetylbenzoazetine (l), N-acetyltetrahydroquinoline (2), and N-acetylbenzazapine (3). The key step is double lithiation of the aryl bromide to give an (o-1ithiophenyl) alkyIlithio- ...