Synthesis of 25-hydroxycholecalcifer-16-en-23-ynol: a potential antipsoriatic agent

M Okabe, RC Sun, M Scalone, CH Jibilian…

文献索引：Okabe; Sun; Scalone; Jibilian; Hutchings Journal of Organic Chemistry, 1995 , vol. 60, # 3 p. 767 - 771

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被引用次数: 24

摘要

It has been shown that la, 25-dihydroxycholecalciferol (1) lJ or its analogs [1a- hydroxycholecalciferol, 2a la, 24-dihydroxycholecalciferol, 3 calcipotriol I have beneficial therapeutic effects in psoriasis, a hyperproliferative skin di~ order.~ However, their clinical use may be limited by