A novel series of thromboxane A2 synthetase inhibitors with free radical scavenging and anti-peroxidative activities.

…, S Nakamura, M Kanda, H Matsui, A Yoshimi…

文献索引：Kamiya; Shirahase; Nakamura; Kanda; Matsui; Yoshimi; Kasai; Takahashi; Kurahashi Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 5 p. 563 - 571

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被引用次数: 12

摘要

A novel series of indoline derivatives with imidazole and carboxyl moieties were synthesized and evaluated for their thromboxane A 2 (TXA 2) synthetase inhibiting, radical scavenging and anti-peroxidative activities. Among the compounds synthesized, 3-{5-substituted-3-[2- (imidazol-1-yl) ethyl] indolin-1-yl} propionic acids showed free radical scavenging activity and inhibitory effects on lipid-peroxidation of rat brain homogenate and on arachidonate- ...