Cinnamic amides of (S)-2-(aminomethyl) pyrrolidines are potent H 3 antagonists

…, I Pettersson, HHF Refsgaard, D Viuff, K Rimvall

文献索引：Peschke, Bernd; Bak, Sonja; Hohlweg, Rolf; Pettersson, Ingrid; Frolund Refsgaard, Hanne Hoffmann; Viuff, Dorthe; Rimvall, Karin Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 10 p. 2603 - 2616

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被引用次数: 32

摘要

New imidazole-free H 3 antagonists have been found in a series of cinnamic amides of (S)-(aminomethyl)pyrrolidines. The influence of the substituent on the aromatic moiety on the potency and the inhibition of three cytochrome P450 subtypes are also described. ... New imidazole-free H 3 antagonists have been found in a series of cinnamic amides of (S)-(aminomethyl)pyrrolidines. The influence of the substituent on the aromatic moiety on ...