Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product
JÁ de la Fuente, S Manzanaro, MJ Martín…
文献索引：De La Fuente, Jesus Angel; Manzanaro, Sonia; Martin, Maria Jesus; De Quesada, Teresa G.; Reymundo, Isabel; Luengo, Santos M.; Gago, Federico Journal of Medicinal Chemistry, 2003 , vol. 46, # 24 p. 5208 - 5221
Aldose reductase (ALR2) has been implicated in the etiology of diabetic complications, including blindness. Because of the limited number of currently available drugs for the prevention of these long-term complications, the discovery of new ALR2 inhibitors appears highly desirable. In this study, a polybrominated diphenyl ether (1) naturally occurring in a marine sponge was found to inhibit recombinant human ALR2 with an IC50 of 6.4 μM. A ...
