Abstract A new class of fused tricyclic benzo [4, 5] imidazo [1, 2-a]-pyrimidine-3-carboxamide derivatives was synthesized via an environmentally benign one pot sequential four- component condensation reaction of an amine, 2, 2, 6-trimethyl-4 H-1, 3-dioxin-4-one, an aldehyde and 1 H-benzo [d] imidazol-2-amine without using catalyst in good yields.