Tetrahedron Letters

Microwave-assisted solvent-free N-arylation of imidazole and pyrazole

WS Chow, TH Chan

文献索引：Chow, Wai Shan; Chan, Tak Hang Tetrahedron Letters, 2009 , vol. 50, # 12 p. 1286 - 1289

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被引用次数: 41

摘要

Cross coupling reactions between N-heterocycles and aryl halides are important for the preparations of many compounds of interest in biological, pharmaceutical and materials sciences. 1 and 2 In particular, N-arylimidazoles of pharmaceutical interest include thromboxane synthase inhibitors, 3 AMPA receptor antagonists, 4 AMP phosphodiesterase inhibitors, 5 cardiotonic agents, 6 and topical anti glaucoma agents. 7 N-Arylpyrazole is a structural element of ...