Design, synthesis, biological evaluation and molecular modeling of 1, 3, 4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents

Y Hu, X Lu, K Chen, R Yan, QS Li, HL Zhu

文献索引：Hu, Yang; Lu, Xiang; Chen, Ke; Yan, Ru; Li, Qing-Shan; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 903 - 909

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被引用次数: 34

摘要

A total of 20 novel 1, 3, 4-oxadiazoline analogs (6a–6t) of combretastatin A-4 with naphthalene ring were designed, synthesized, and evaluated for biological activities as potential tubulin polymerization inhibitors. Among these compounds, 6n showed the most potent antiproliferative activities against multiple cancer cell lines and retained the microtubule disrupting effects. Docking simulation was performed to insert compound 6n ...