Asymmetric iodocyclization catalyzed by salen–criiicl: its synthetic application to swainsonine

HY Kwon, CM Park, SB Lee, JH Youn…

文献索引：Kwon, Hyo Young; Park, Chul Min; Lee, Sung Bae; Youn, Joo-Hack; Kang, Sung Ho Chemistry - A European Journal, 2008 , vol. 14, # 3 p. 1023 - 1028

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被引用次数: 83

摘要

Abstract The previously developed enantioselective iodocyclization of γ-hydroxy-cis-alkenes required 30 mol% of (R, R)-salen–Co II complex as chiral catalyst and 0.75 equivalent of N- chlorosuccinimide (NCS) as activator to produce 2-substituted tetrahydrofurans with 61 to 90% ee. Due to the considerable loading amount of the Co II complex, another more effective catalyst was pursued by screening (R, R)-salen–transition metal complexes. ...