Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholinothieno [3, 2-d] pyrimidine derivatives as potential antitumor agents

…, X Wang, Y Zhu, D Wu, H Zhou, P Gong, Y Zhao

文献索引：Zhu, Wufu; Liu, Yajing; Zhai, Xin; Wang, Xiao; Zhu, Yan; Wu, Di; Zhou, Hongyu; Gong, Ping; Zhao, Yanfang European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 162 - 175

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被引用次数: 14

摘要

A series of 2-hydrazinyl-4-morpholinothieno [3, 2-d] pyrimidine derivatives were synthesized and evaluated for their cytotoxic activities against five cancer cell lines. Most of them exhibited moderate to significant cytotoxic activities and high-selectivity against one or more cell lines, and nearly all of them had higher potency than positive controls against MDA-MB- 231 cell line. The most promising compound 15f showed strong cytotoxic activities against ...