Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities

…, BI Florea, M Ruben, GA van der Marel…

文献索引：Willems, Lianne I.; Li, Nan; Florea, Bogdan I.; Ruben, Mark; Van Der Marel, Gijsbert A.; Overkleeft, Herman S. Angewandte Chemie - International Edition, 2012 , vol. 51, # 18 p. 4431 - 4434

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被引用次数: 67

摘要

Bioorthogonal chemistry plays an important role in chemical biology research by creating the means to carry out selective chemical transformations in complex biological samples. A ligation reaction classifies as being bioorthogonal when it can be performed in a biological sample in a chemoselective manner without any interference with the biological system. Bioorthogonal reactions have been used in cell-surface labeling of glycoproteins and ...