Journal of fluorine chemistry

The new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4-hydroxy-3- …

H Cai, D Yin, L Zhang, Y Wang

文献索引：Cai, Hancheng; Yin, Duanzhi; Zhang, Lan; Wang, Yongxian Journal of Fluorine Chemistry, 2006 , vol. 127, # 7 p. 837 - 841

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被引用次数: 8

摘要

9-(4-Hydroxy-3-hydroxymethylbutyl) guanine (Penciclovir) is a potent and selective inhibitor of members of the herpes virus family. A new convenient synthesis of fluorinated Penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (FHBG) and 2-amino-6-fluoro-9-(4- hydroxy-3-hydroxy-methylbutyl) purine (6-Fluoropenciclovir) were described. The structures of the products were characterized by UV, IR, 1H NMR, 19F NMR spectra and MS.