Synthesis and dopaminergic activity of some 3-(1, 2, 3, 6-tetrahydro-1-pyridylalkyl) indoles. A novel conformational model to explain structure-activity relationships

H Böttcher, G Barnickel, HH Hausberg…

文献索引：Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026

全文：HTML全文

被引用次数: 27

摘要

The synthesis and dopaminergic properties of a novel type of dopamine agonist is described. The number and kind of essential structural elements differ significantly from that of the rigid apomorphine-type dopamine agonists. Using standard molecular modeling techniques, a conformational model is developed proposing a U-shaped conformation which might be energetically preferred through aromatic rdnteractions between both of the ...