Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1, 2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase …

MA Chowdhury, Z Huang, KRA Abdellatif…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 19 p. 5776 - 5780

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被引用次数: 12

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Chemical structures of some representative iron-chelating 5-LOX inhibitors (1–2), a COX-2/5-LOX inhibitor (3), a selective COX-2 inhibitor (4), dual COX/5-LOX inhibitors (5–7) and the non-selective COX-1/COX-2 inhibitor (8). ...