Carboxylate??Directed Tandem Functionalisations of α, β??Dihaloalkenoic Acids with 1??Alkynes: A Straightforward Access to (Z)??Configured, α, β??Substituted γ?? …
Butenolides 1 represent an important class of naturally occurring lactones. Among them, 3- substituted and 3, 4-substituted 5-ylidene-5H-furan-2-ones are of continuous interest as synthetic targets, and some of the substances presenting these moieties display a wide range of biological activities. Very simple examples of these substances include molecules, such as tetrenolin,[1] which displays antibiotic activity, the cytotoxic and herbicidal ...
